Nicotine reverses anhedonic-like response and cognitive impairment in the rat chronic mild stress model of depression: comparison with sertraline.

@article{Andreasen2011NicotineRA,
  title={Nicotine reverses anhedonic-like response and cognitive impairment in the rat chronic mild stress model of depression: comparison with sertraline.},
  author={Jesper Tobias Andreasen and Kim Henningsen and Simon Bate and Sofie Christiansen and Ove Wiborg},
  journal={Journal of psychopharmacology},
  year={2011},
  volume={25 8},
  pages={1134-41}
}
Smoking rates among depressed individuals are higher than is observed in the background population, and nicotine alleviates depressive symptoms. In rodents, nicotine shows antidepressant-like effects in the forced swim and learned helplessness paradigms. Clinical depression is associated with both anhedonia and cognitive impairments. In rats, chronic mild stress (CMS) decreases voluntary sucrose intake, reflecting an anhedonic-like state, and impairs performance in the spontaneous alternation… CONTINUE READING

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Clinical depression is associated with both anhedonia and cognitive impairments .
Clinical depression is associated with both anhedonia and cognitive impairments .
Nicotine reverses anhedonic - like response and cognitive impairment in the rat chronic mild stress model of depression : comparison with sertraline .
Clinical depression is associated with both anhedonia and cognitive impairments .
Clinical depression is associated with both anhedonia and cognitive impairments .
Clinical depression is associated with both anhedonia and cognitive impairments .
Clinical depression is associated with both anhedonia and cognitive impairments .
Clinical depression is associated with both anhedonia and cognitive impairments .
Clinical depression is associated with both anhedonia and cognitive impairments .
Clinical depression is associated with both anhedonia and cognitive impairments .
Clinical depression is associated with both anhedonia and cognitive impairments .
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