Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies.

@article{Alzoubi2006NicotineRA,
  title={Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies.},
  author={Karem H Alzoubi and Abdulaziz Mohammed Aleisa and Nashaat Z. Gerges and Karim A Alkadhi},
  journal={Journal of neuroscience research},
  year={2006},
  volume={84 5},
  pages={944-53}
}
Nicotine alleviates cognitive impairment associated with a variety of health conditions. We examined the effect of chronic nicotine treatment on adult-onset hypothyroidism-induced impairment of learning and memory in rats. Hypothyroidism was induced by surgical removal of thyroid glands (thyroidectomy). One month later, chronic nicotine treatment (1 mg/kg sc, twice/day) was instituted for 4-6 weeks. Test of hippocampus-dependent spatial learning and memory in the radial arm water maze showed… CONTINUE READING
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