Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice.

@article{Sood2011NicotineRO,
  title={Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice.},
  author={Nimisha Sood and Debasish Hota and Ashok Kumar Sahai and Amitava Chakrabarti},
  journal={Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco},
  year={2011},
  volume={13 11},
  pages={1084-91}
}
INTRODUCTION Tobacco smoking is a widespread phenomenon, and nicotine is the addictive component of tobacco. Nicotine acts through nicotinic cholinergic receptors and has been associated with different types of psychophysical disorders in human beings. The present study had explored the proconvulsive action of nicotine and its effect on the antiseizure efficacy of topiramate against kainic acid (KA)-induced seizures in mice. METHODS The study had evaluated the dose-response curves for… CONTINUE READING