Nicotine replacement therapy in pregnancy and major congenital anomalies in offspring.

@article{Dhalwani2015NicotineRT,
  title={Nicotine replacement therapy in pregnancy and major congenital anomalies in offspring.},
  author={Nafeesa N Dhalwani and Lisa Catherine Szatkowski and Tim Coleman and Linda Fiaschi and Laila J Tata},
  journal={Pediatrics},
  year={2015},
  volume={135 5},
  pages={
          859-67
        }
}
BACKGROUND AND OBJECTIVES Nicotine replacement therapy (NRT) is now being used as a smoking cessation aid during pregnancy, although little is known about fetal safety. We assessed the relationship between early pregnancy exposure to NRT or smoking with major congenital anomalies (MCA) in offspring. METHODS We studied 192,498 children born in the United Kingdom between 2001 and 2012 with linked mother-child primary care records. The absolute risks of MCAs in the NRT group (women prescribed… CONTINUE READING
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