Nicotine psychopharmacology research contributions to United States and global tobacco regulation: a look back and a look forward

  title={Nicotine psychopharmacology research contributions to United States and global tobacco regulation: a look back and a look forward},
  author={Jack E. Henningfield and Mitch Zeller},
Nicotine has a long and storied history in physiology and pharmacology. Historically, it has been used as a tool to explore the nervous system, studied for its role in tobacco use, and more recently examined for its diverse potential medicinal uses. Psychopharmacology research has been pivotal in the science foundation for nicotine and tobacco product regulation. 

Physiology of Nicotine

The nicotine content of popular American-brand cigarettes has slowly increased over the years, and one study found that there was an average increase of 1.78 % per year between the years of 1998 and 2005.

Nicotine psychopharmacology: policy and regulatory.

Psychopharmacological research on nicotine and tobacco was important in the rationale and development of the Framework Convention on Tobacco Control, and the public health relevance of psychopharmacology research continues to grow with the realization of the potential of nicotine and related drugs to treat or prevent a diverse range of disorders.

Behavioral pharmacology contributions to regulation of drug and tobacco products by the Food and Drug Administration.

Behavioral pharmacology methods and strategies are increasingly relied upon by the Food and Drug Administration (FDA) for its regulation of drug and tobacco products due to the reliability, validity,

Nicotine addiction and its Pharmacological effects: A Review

Based on the finding that the chemical nicotine is the key addictive component of tobacco, scientists developed nicotine replacement strategies including the nicotine patch, the nicotine inhaler, and nicotine gum.

Tobacco psychopharmacology and public health policy: it takes a community.

An overview of how advances utilizing animal and human models of dependence and withdrawal came to inform public health policy and more recently, tobacco product regulation and how efforts by the tobacco industry collided with those of non industry researchers, including Division 28 members are recounted.

Nicotine self-administration research: the legacy of Steven R. Goldberg and implications for regulation, health policy, and research

This review includes a review of intravenous nicotine self-administration research from the 1960s to 2016 to summarize and put into historical perspective Goldberg’s contributions to elucidate the reinforcing effects of nicotine and the implications of his research for medication development, tobacco regulation, and potential tobacco control policy options.

Smoking, nicotine and neuropsychiatric disorders

Pharmaceutical Incursion on Cigarette Smoking at the Birth of the Brain Disease Model of Addiction

As relapse to smoking has remained the most likely outcome of any smoking cessation attempt, so medicinal nicotine has also served to demonstrate that nicotine addiction is ultimately a problem of an uncontrollable appetite for cigarettes in excess of drug dependence.

Molecular mechanisms for nicotine intoxication

Animal models of cannabinoid reward

Work with animal models of cannabinoid reward indicates that cannabinoid reward involves similar brain mechanisms and produces the same kinds of reward‐related behaviour, and it should be possible to take advantage of the potential benefits provided by the endocannabinoid system while minimizing its potential for harm.



Nicotine analogues: a review of tobacco industry research interests.

The tobacco industry's interest and intentions driving its nicotine analogue research are explored, which has led to potential therapeutic uses for Alzheimer's and Parkinson's diseases and alarmingly for the industry, to a potential vaccine to prevent nicotine addiction.

Tobacco addiction: accomplishments and challenges in science, health, and policy.

  • C. Koop
  • Political Science
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • 2003
It is an unusual pleasure to have the opportunity to speak to so many of the world’s leaders in the science of tobacco and nicotine, and to spend a few minutes reflecting on what I see as some of your opportunities as scientists and contributors to the welfare of global society.

Pharmacotherapy for Nicotine Dependence 1

Combination therapies, long‐term medication therapies, and harm reduction strategies may further improve outcome with approved medications, and new medications such as varenicline and rimonabant are likely to reach tobacco users who are refractory to current treatments.

Influencing cigarette smoking with nicotine antagonists

Different results with mecamylamine and pentolinium support previous evidence that the action of nicotine in the central nervous system has a small but clearly demonstrable role as a primary reinforcer of the smoking habit.

A substitute for tobacco smoking

A chewing gum containing nicotine bound to an ion exchanger was deviced to be used for smoking withdrawal because it allows administration in a convenient way of nicotine ad libitum, it precludes intoxication of the preparation if swallowed and it allows reducing the nicotine content for withdrawal purposes while keeping other properties unchanged.

Tobacco and public health : science and policy

This book is mandatory reading for everyone engaged in the combat of this health catastrophe, and the editors must be complimented for having composed a comprehensive and broad-spectrum book on this manmade, health-care complex issue of unimaginable size.

Pharmacotherapy of nicotine dependence.

  • K. Haustein
  • Medicine
    International journal of clinical pharmacology and therapeutics
  • 2000
Treatment with nicotine substitution preparations has shown confirmed efficacy in numerous studies and results in successful withdrawal from the smoking habit in 30-40% of cases, and non-drug methods such as hypnosis therapy and acupuncture are not effective.

Abuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine.

The hypothesis that the Role of nicotine in tobacco dependence is equivalent to the role of other psychoactive drugs in substance abuse, e.g., to the roles of cocaine in coca leaf use is supported.

Nicotine self-administration in animals as a dependence model.

  • W. Corrigall
  • Biology, Psychology
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • 1999
This manuscript describes the use of one particular paradigm, a model in which work is done by laboratory animals to obtain intravenous infusions of nicotine, which is particularly useful for examining the mechanisms in the brain that are responsible for the maintenance of drug-taking behavior.

Nicotine and addiction. The Brown and Williamson documents.

The documents reveal an intention on the part of B&W and its corporate parent to affect the function of the body with nicotine.