Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2.

@article{Shin2004NicotinePG,
  title={Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2.},
  author={Vivian Yvonne Shin and William Ka-Kei Wu and Yi-ni Ye and Wallace Hau Leung So and Marcel Wing-leung Koo and Edgar Shiu-Lam Liu and Jiing-Chyuan Luo and Chi-hin Cho},
  journal={Carcinogenesis},
  year={2004},
  volume={25 12},
  pages={2487-95}
}
Early studies revealed that cigarette smoke promotes gastric cancer growth through the induction of cyclooxygenase-2 (COX-2). Nicotine, one of the active ingredients in cigarette smoke, has detrimental effects in the stomach. To date, there is no direct evidence to validate the effect of nicotine on gastric tumor growth and its carcinogenic mechanism(s). We therefore investigated whether nicotine could promote tumor growth and neovascularization in vivo, and the biological mechanism(s) in… CONTINUE READING

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