Nicotine promotes atherosclerosis development in apolipoprotein E-deficient mice through α1-nAChR.

@article{Ren2018NicotinePA,
  title={Nicotine promotes atherosclerosis development in apolipoprotein E-deficient mice through α1-nAChR.},
  author={Anmin Ren and Hongxian Wu and Li-ping Liu and Zhenzhen Guo and Qunan Cao and Qiuyan Dai},
  journal={Journal of cellular physiology},
  year={2018}
}
α1 Nicotinic acetylcholine receptor (α1nAChR) is an important nicotine receptor that is widely distributed in vascular smooth muscle cells, macrophages, and endothelial cells. However, the role of α1nAChR in nicotine-mediated atherosclerosis remains unclear. The administration of nicotine for 12 weeks increased the area of the atherosclerotic lesion, the number of macrophages infiltrating the plaques, and the circulating levels of inflammatory cytokines, such as interleukin-6 and tumor necrosis… CONTINUE READING
1
Twitter Mention