Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.

@article{Ye2004NicotinePC,
  title={Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.},
  author={Yi Ni Ye and Edgar Shiu-Lam Liu and Vivian Yvonne Shin and William K K Wu and Jiing Chyuan Luo and Chi Hin Cho},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={308 1},
  pages={
          66-72
        }
}
  • Yi Ni Ye, Edgar Shiu-Lam Liu, +3 authors Chi Hin Cho
  • Published 2004
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco, has been implicated as playing a role in carcinogenesis. Our previous study showed that passive cigarette smoking promoted inflammation-associated colonic adenoma formation in mice, and 5-lipoxygenase (5-LOX) plays an important role in this process. In the present study, we aimed to investigate whether nicotine could stimulate colon cancer cell proliferation and tumor growth in nude mice xenograft model and the… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 34 REFERENCES

    Involvement of 5-lipoxygenase, matrix metalloproteinase-2 and vascular endothelial growth factor in the colonic tumorigenesis promoted by passive cigarette smoking

    • YN Ye, ESL Liu, VY Shin, CH Cho
    • Am Assoc Cancer Res
    • 2003
    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL

    Functional implication of the interaction between EGF receptor and c-Src.

    VIEW 1 EXCERPT

    Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants.

    VIEW 1 EXCERPT

    MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression.

    VIEW 1 EXCERPT