Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor.

@article{Meyer2002NicotinePA,
  title={Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor.},
  author={Erin L Meyer and Lorise C Gahring and Scott Warren Rogers},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 13},
  pages={10869-75}
}
Neuronal excitation is required for normal brain function including processes of learning and memory, yet if this process becomes dysregulated there is reduced neurotransmission and possibly death through excitotoxicity. Nicotine, through interaction with neuronal nicotinic acetylcholine receptors, possesses the ability to modulate neurotransmitter systems… CONTINUE READING