Nicotine potentiates the effects of haloperidol in animals and in patients with Tourette syndrome.

@article{Sanberg1989NicotinePT,
  title={Nicotine potentiates the effects of haloperidol in animals and in patients with Tourette syndrome.},
  author={Paul R. Sanberg and Brian J McConville and H M Fogelson and P Z Manderscheid and Kenneth W. Parker and M M Blythe and William M Klykylo and Andrew B. Norman},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={1989},
  volume={43 1},
  pages={19-23}
}
Nicotine was found to markedly potentiate haloperidol-induced hypokinesia in rats. Nicotine alone was without effect. Subsequently, concurrent administration of 2 mg nicotine gum to 10 Tourette syndrome patients being treated with haloperidol produced a substantial decrease in tics and improvement of concentration and attention span. Nicotine gum alone was without effect. While 80% of children showed improvement with nicotine gum, 70% completely discontinued the gum because of side-effects… CONTINUE READING

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