Nicotine modulates the long-lasting storage of fear memory.

  title={Nicotine modulates the long-lasting storage of fear memory.},
  author={Ram{\'o}n Hypolito Lima and Andressa Radiske and Cristiano Andr{\'e} K{\"o}hler and Mar{\'i}a Carolina Vera Gonz{\'a}lez and Lia Rejane M. Bevilaqua and Janine I Rossato and Jorge H Medina and Mart{\'i}n Cammarota},
  journal={Learning & memory},
  volume={20 3},
Late post-training activation of the ventral tegmental area (VTA)-hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated… CONTINUE READING


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