Nicotine modulates the immunological function of dendritic cells through peroxisome proliferator-activated receptor-γ upregulation.

@article{Yanagita2012NicotineMT,
  title={Nicotine modulates the immunological function of dendritic cells through peroxisome proliferator-activated receptor-γ upregulation.},
  author={Manabu Yanagita and Ryohei Kobayashi and Yuko Kojima and Kenta Mori and Shinya Murakami},
  journal={Cellular immunology},
  year={2012},
  volume={274 1-2},
  pages={26-33}
}
We examined the effects of nicotine on differentiation and function of monocyte-derived human dendritic cells (DCs). NiDCs, which were the DCs differentiated in the presence of nicotine, showed lower levels of CD1a. Secretion of IL-12 and TNF-α by lipopolysaccharide (LPS)-stimulated NiDCs was significantly suppressed compared to monocyte-derived DCs grown without nicotine. NiDCs displayed a diminished capacity to induce allogeneic T cell proliferation with a reduced production of IFN-γ, and… CONTINUE READING
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