Nicotine-modulated subunit stoichiometry affects stability and trafficking of α3β4 nicotinic receptor.

@article{Mazzo2013NicotinemodulatedSS,
  title={Nicotine-modulated subunit stoichiometry affects stability and trafficking of α3β4 nicotinic receptor.},
  author={Francesca Mazzo and Francesco Pistillo and Giovanni Grazioso and Francesco Clementi and Nica Borgese and Cecilia Gotti and Sara Francesca Colombo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 30},
  pages={12316-28}
}
Heteromeric nAChRs are pentameric cation channels, composed of combinations of two or three α and three or two β subunits, which play key physiological roles in the central and peripheral nervous systems. The prototypical agonist nicotine acts intracellularly to upregulate many nAChR subtypes, a phenomenon that is thought to contribute to the nicotine dependence of cigarette smokers. The α3β4 subtype has recently been genetically linked to nicotine dependence and lung cancer; however, the mode… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2007
View 5 Excerpts
Highly Influenced

Nicotinic mechanisms in the autonomic control of organ systems.

Journal of neurobiology • 2002
View 5 Excerpts
Highly Influenced

Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells

L Riganti, C Matteoni, +6 authors C Gotti
Br J Pharmacol • 2005
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…