Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity.

@article{Dempsey2004NicotineMR,
  title={Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity.},
  author={Delia A. Dempsey and Piotr Tutka and Peyton Jacob and Faith Allen and Kerri Alexandra Schoedel and Rachel F. Tyndale and Neal L. Benowitz},
  journal={Clinical pharmacology and therapeutics},
  year={2004},
  volume={76 1},
  pages={64-72}
}
BACKGROUND Nicotine and a variety of other drugs and toxins are metabolized by cytochrome P450 (CYP) 2A6. Our objective was to evaluate the use of oral nicotine with measurement of the trans-3'-hydroxycotinine (3HC)/cotinine (COT) metabolite ratio as a noninvasive probe of CYP2A6 activity. METHODS Sixty-two healthy volunteers received an oral solution of deuterium-labeled nicotine (2 mg) and its metabolite cotinine (10 mg). Plasma nicotine and plasma and saliva cotinine and 3HC concentrations… CONTINUE READING
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