Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.

@article{Qiao2003NicotineIA,
  title={Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.},
  author={Dan Qiao and Frederic J. Seidler and Jonathan D. Violin and Theodore A. Slotkin},
  journal={Brain research. Developmental brain research},
  year={2003},
  volume={147 1-2},
  pages={183-90}
}
Although nicotine is now well recognized as a developmental neurotoxicant, it also may have neuroprotectant properties. In the current study, we used PC12 cells to characterize the specific developmental phases in which these effects are expressed. In undifferentiated cells, nicotine had a modest effect on DNA synthesis (10% reduction), which was nevertheless selective, as no significant reductions were seen for RNA or protein synthesis. The effects were blocked by mecamylamine, indicating… CONTINUE READING

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