Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.

@article{Liu2004NicotineIV,
  title={Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.},
  author={Lieju Liu and Wenheng Zhu and Z-S Zhang and Tianming Yang and Andrew A. T. Grant and Gary Oxford and Sidney Arthur Simon},
  journal={Journal of neurophysiology},
  year={2004},
  volume={91 4},
  pages={1482-91}
}
Nicotine is an alkaloid that is used by large numbers of people. When taken into the body, it produces a myriad of physiological actions that occur primarily through the activation of neuronal nicotinic acetylcholine receptors (nAChRs). We have explored its ability to modulate TRPV1 receptors and voltage-gated sodium channels. The reason for investigating nicotine's effect on sodium channels is to obtain a better understanding of its anti-nociceptive properties. The reasons for investigating… CONTINUE READING