Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin.

@article{Dasgupta2006NicotineIA,
  title={Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin.},
  author={Piyali Dasgupta and Rebecca Kinkade and Bharat Chandra Joshi and Christina Decook and Eric B. Haura and Srikumar Chellappan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 16},
  pages={
          6332-7
        }
}
Non-small cell lung cancer (NSCLC) demonstrates a strong etiologic association with smoking. Although nicotine is not carcinogenic, it can induce cell proliferation and angiogenesis and suppress apoptosis induced by certain agents. Here we show that nicotine inhibits apoptosis induced by the drugs gemcitabine, cisplatin, and taxol, which are used to treat NSCLCs. This protection correlated with the induction of XIAP and survivin by nicotine in a panel of human NSCLC cell lines, and depletion of… CONTINUE READING
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