Nicotine induces uncoupling protein 1 in white adipose tissue of obese mice

  title={Nicotine induces uncoupling protein 1 in white adipose tissue of obese mice},
  author={Toshihide Yoshida and Naoki Sakane and Tsunekazu Umekawa and Akinori Kogure and Motoharu Kondo and Kazumasa Kumamoto and Teruo Kawada and Itsuro Nagase and Masayuki U. Saito},
  journal={International Journal of Obesity},
OBJECTIVE: To test the hypothesis that nicotine not only activates uncoupling protein1 (UCP1) in brown adipose tissue (BAT), but also induces UCP1 in white adipose tissue (WAT), which contributes to the mitigation of obesity in obese mice.DESIGN: Weights of the whole body, the gastrocnemius muscle, interscapular BAT and subcutaneous and retroperitoneal WAT, food intake and the mRNA and protein of UCP1 in these tissues were measured and immunohistochemistry using antiserum against UCP1 was also… CONTINUE READING


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Effects of nicotine on norepinephrine turnover of mice subjected to emotional stress

T Yoshida, T Umekawa, N Sakane, K Yoshimoto, M. Kondo
Pathophysiology • 1995

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