Nicotine induces conditioned place preferences over a large range of doses in rats

  title={Nicotine induces conditioned place preferences over a large range of doses in rats},
  author={B. Le Foll and S. R. Goldberg},
  • B. Le Foll, S. R. Goldberg
  • Published 2004
  • Psychology, Medicine
  • Psychopharmacology
  • RationaleConditioned place preference (CPP) procedures provide one measure of potential rewarding effects of abused drugs. Many attempts to induce CPP with nicotine have been unsuccessful.ObjectivesTo assess the influence of nicotine dose and stimulus assignment procedure on development of nicotine-induced CPP.MethodsInitial preferences for one side of a two-compartment apparatus were first determined in Sprague–Dawley rats. In subsequent conditioning trials, the compartment paired with… CONTINUE READING
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