Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines.

@article{Dasgupta2009NicotineIC,
  title={Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines.},
  author={Piyali Dasgupta and Wasia Rizwani and Smitha R Pillai and Rebecca Kinkade and Michelle Kovacs and Shipra Rastogi and Sarmistha Banerjee and Melanie A. Carless and Esther Lee Kim and Domenico Coppola and Eric B. Haura and Srikumar Chellappan},
  journal={International journal of cancer},
  year={2009},
  volume={124 1},
  pages={36-45}
}
Cigarette smoking is strongly correlated with the onset of nonsmall cell lung cancer (NSCLC). Nicotine, an active component of cigarettes, has been found to induce proliferation of lung cancer cell lines. In addition, nicotine can induce angiogenesis and confer resistance to apoptosis. All these events are mediated through the nicotinic acetylcholine receptors (nAChRs) on lung cancer cells. In this study, we demonstrate that nicotine can promote anchorage-independent growth in NSCLCs. In… CONTINUE READING
137 Citations
62 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 137 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Similar Papers

Loading similar papers…