Nicotine induces DNA damage in human salivary glands.

@article{Ginzkey2009NicotineID,
  title={Nicotine induces DNA damage in human salivary glands.},
  author={Christian Ginzkey and Katja Kampfinger and Gudrun Friehs and Christian Koehler and Rudolf Hagen and E. -I. Richter and Norbert Helmut Kleinsasser},
  journal={Toxicology letters},
  year={2009},
  volume={184 1},
  pages={1-4}
}
The tobacco alkaloid nicotine is responsible for addiction to tobacco and supposed to contribute to tobacco carcinogensis, too. Recently, genotoxic effects of nicotine have been reported in human cells from blood and upper aerodigestive tract. Because of nicotine accumulation in saliva, the study of possible in vitro genotoxic effects of nicotine have been extended to human salivary gland cells. Specimens of parotid glands of 10 tumor patients were obtained from tumor-free tissue. Single cells… CONTINUE READING
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