Nicotine induced proliferation and cytokine release in osteoblastic cells.

@article{Kamer2006NicotineIP,
  title={Nicotine induced proliferation and cytokine release in osteoblastic cells.},
  author={Angela R. Kamer and Nada El-Ghorab and Nancy Marzec and Joseph E. Margarone and Rosemary Dziak},
  journal={International journal of molecular medicine},
  year={2006},
  volume={17 1},
  pages={121-7}
}
Smoking has deleterious effects on osteoporosis and periodontitis both characterized by bone loss. Smoking also interferes with the protective effect that hormone replacement therapy (HRT) has on bone loss. Our study investigated two mechanisms by which smoking may affect bone metabolism: nicotine-induced proliferation and nicotine-induced cytokine secretion in osteoblasts. Two osteoblastic cell models were used: mouse osteoblasts derived from mouse calvaria and human osteoblasts. Thymidine… CONTINUE READING