Nicotine-induced hypothermia through an indirect dopaminergic mechanism.

Abstract

The effect of nicotine on core body temperature was studied in mice. Intraperitoneal (i.p.) injection of nicotine (0.5, 1 and 2 mg/kg) induced a dose-dependent hypothermia. The response was inhibited by reserpine (5 mg/kg), the centrally active nicotinic receptor antagonist mecamylamine (0.1-1 mg/kg) and the D-2 dopamine receptor antagonist sulpiride (25… (More)
DOI: 10.1177/026988119500900104

7 Figures and Tables

Topics

  • Presentations referencing similar topics