Nicotine-induced enhancements in the five-choice serial reaction time task in rats are strain-dependent

Abstract

Rationale: Clinically, nicotine improves attention, but this has proven difficult to demonstrate preclinically. We tested nicotine in Sprague-Dawley (SD) and Lister hooded (LH) rats in the five-choice serial reaction time task. Since SD rats demonstrate lower asymptotic performance than LH rats, we surmised that nicotine would only improve performance in… (More)
DOI: 10.1007/s002130000605

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