Nicotine-induced conditioned place preference in adolescent rats.

  title={Nicotine-induced conditioned place preference in adolescent rats.},
  author={Reka Natarajan and John W. Wright and Joseph W. Harding},
  journal={Pharmacology, biochemistry, and behavior},
  volume={99 3},
A number of clinical reports have noted that women are more vulnerable to tobacco abuse than men, and adolescent females are especially vulnerable to nicotine addiction. Conditioned place preference (CPP) is a widely used technique for determining the rewarding effects of drugs with abuse potential in animal models. Several studies have reported that nicotine was ineffective in eliciting CPP in rats; while others have observed conditioned place aversion (CPA) rather than preference for nicotine… CONTINUE READING