Nicotine-induced FGF-2 mRNA in rat brain is preserved during aging.

  title={Nicotine-induced FGF-2 mRNA in rat brain is preserved during aging.},
  author={Natale Belluardo and Giuseppa Mud{\`o} and Mariann Blum and Nobuyuki Itoh and Luigi Agnati and Kjell Fuxe},
  journal={Neurobiology of aging},
  volume={25 10},
Indirect trophic actions of nicotine on brain during aging are suggested from observations describing nicotine as a cognitive enhancer, increasing vigilance and improving learning and memory, and both in vitro and in vivo models have demonstrated neuroprotective effects of nAChR agonists. Previously, we have reported that an acute intermittent (-)nicotine treatment significantly increases fibroblast growth factor-2 (FGF-2) mRNA and protein in several brain regions of rat brain. The present… CONTINUE READING
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