Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo.

@article{Jonnala2002NicotineIT,
  title={Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo.},
  author={Ramamohana R. Jonnala and Alvin V. Terry and Jerry J. Buccafusco},
  journal={Life sciences},
  year={2002},
  volume={70 13},
  pages={
          1543-54
        }
}
Impairment in nerve growth factor (NGF)-mediated support to basal forebrain cholinergic neurons may represent an initial insult to certain neural cells in Alzheimer's disease (AD). High affinity NGF receptor (TrkA) levels are decreased in AD brains as compared to age-matched control brains. One of the approaches suggested for the treatment of AD exploits the ability of small molecular substances to enhance the expression of endogenous growth factors and/or their receptors. The purpose of this… CONTINUE READING

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