Nicotine increases size and severity of experimental choroidal neovascularization.

  title={Nicotine increases size and severity of experimental choroidal neovascularization.},
  author={Ivan J. Su{\~n}er and Diego G. Espinosa-Heidmann and Maria Encarna Marin-Casta{\~n}o and Eleut P. Hernandez and Simone Pereira-Simon and Scott W. Cousins},
  journal={Investigative ophthalmology & visual science},
  volume={45 1},
PURPOSE Cigarette smoking is the strongest environmental risk factor for all forms of age-related macular degeneration (AMD). In the present study, the influence of nicotine on the severity of choroidal neovascularization (CNV) in a mouse model of neovascular AMD and its effects on vascular smooth muscle cells derived from mouse choroid were investigated. METHODS A mouse model for CNV was used to study the effects of nicotine in young and middle-aged mice. Nicotine was administered orally in… CONTINUE READING
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