Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution.

@article{Hawkins2004NicotineII,
  title={Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution.},
  author={Brian T Hawkins and Thomas J. Abbruscato and Richard D. Egleton and Rachel Clare Brown and Jason Delwyn Huber and Christopher R Campos and Thomas P Davis},
  journal={Brain research},
  year={2004},
  volume={1027 1-2},
  pages={48-58}
}
The blood-brain barrier (BBB) is critical to the health of the central nervous system. The BBB is formed primarily by the presence of tight junctions (TJ) between cerebral microvessel endothelial cells. In light of the known effects of nicotine on endothelial cell biology, the specific effects of nicotine on the in vivo BBB were examined. Using in situ brain perfusion, it was found that continuous administration of nicotine (4.5 mg free base x kg(-1) x day(-1)) for 1 and 7 days led to increased… CONTINUE READING