Nicotine increases expression of tyrosine hydroxylase gene. Involvement of protein kinase A-mediated pathway.

@article{Hiremagalur1993NicotineIE,
  title={Nicotine increases expression of tyrosine hydroxylase gene. Involvement of protein kinase A-mediated pathway.},
  author={Bhargava Hiremagalur and Bistra B Nankova and Jim Nitahara and R J Zeman and Esther L. Sabban},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 31},
  pages={
          23704-11
        }
}
Nicotine, a major component of tobacco smoke, stimulates catecholamine secretion and activates catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medullary cells. We investigated the effect of long term treatment with nicotine on TH and DBH gene expression in rat PC12 pheochromocytoma cells. Nicotine treatment for 1-2 days increased both the TH and DBH mRNA levels. The effect of nicotine on TH mRNA seems to be transcriptionally… CONTINUE READING
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