Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats

@article{L2002NicotineIA,
  title={Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats},
  author={A. D. L{\^e} and Aili Wang and Stephen Harding and Walter Juzytsch and Yavin Shaham},
  journal={Psychopharmacology},
  year={2002},
  volume={168},
  pages={216-221}
}
Alcohol and tobacco are often co-abused in humans and previous studies found that nicotine increases alcohol consumption in rats. Here, we studied whether nicotine would reinstate alcohol-taking behavior in drug-free rats and whether this effect would be enhanced by prior exposure to nicotine during alcohol self-administration training. Rats were trained to press a lever for alcohol (12% w/v, 1 h/day), and following stable alcohol intake groups of rats (n=11–12) were given daily vehicle or… CONTINUE READING

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