Nicotine impairs cyclooxygenase-2-dependent kinin-receptor-mediated murine airway relaxations.

Abstract

INTRODUCTION Cigarette smoke induces local inflammation and airway hyperreactivity. In asthmatics, it worsens the symptoms and increases the risk for exacerbation. The present study investigates the effects of nicotine on airway relaxations in isolated murine tracheal segments. METHODS Segments were cultured for 24h in the presence of vehicle, nicotine… (More)
DOI: 10.1016/j.taap.2013.12.013

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