Nicotine hapten structure, antibody selectivity and effect relationships: results from a nicotine vaccine screening procedure.

@article{Villiers2010NicotineHS,
  title={Nicotine hapten structure, antibody selectivity and effect relationships: results from a nicotine vaccine screening procedure.},
  author={Sabina H. L. de Villiers and Nina Lindblom and Genadiy Kalayanov and Sandra Gordon and Ivan L. Baraznenok and Anna Malmerfelt and Monica Marcus and Anette M. Johansson and Torgny H. Svensson},
  journal={Vaccine},
  year={2010},
  volume={28 10},
  pages={2161-8}
}
The aim of the present study was to synthesise and screen a set of novel nicotine hapten immunogens used for the treatment of nicotine dependence. In the screening process we studied the amount of antibodies generated and their selectivity, using ELISA techniques, and their effects on nicotine-induced dopamine release in the NAC(shell) of the rat, assessed by in vivo voltammetry. We conclude that even small changes such as the linker attachment on the nicotine molecule as well as the structure… CONTINUE READING

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