Nicotine exposure reduces N-methyl-D-aspartate toxicity in the hippocampus: relation to distribution of the alpha7 nicotinic acetylcholine receptor subunit.

@article{Prendergast2001NicotineER,
  title={Nicotine exposure reduces N-methyl-D-aspartate toxicity in the hippocampus: relation to distribution of the alpha7 nicotinic acetylcholine receptor subunit.},
  author={Mark A. Prendergast and Barton R Harris and Sveta Mayer and Robert C Holley and James R. Pauly and John Martin Littleton},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2001},
  volume={7 6},
  pages={1153-60}
}
BACKGROUND Exposure to nicotine has been shown to promote neuronal survival after excitotoxic insult to the brain. The role of specific nicotinic acetylcholine receptors (nAChRs) subtypes in mediating this effect is not well understood, however. Examination of distinct receptor subtypes in promoting neuronal survival is of importance not only in understanding the regulation of necrotic cell death but potentially in the development of novel pharmacological therapies that may reduce this form of… CONTINUE READING
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