Nicotine exposure alters the mRNA expression of Notch ligands in dendritic cells and their response to Th1-/Th2-promoting stimuli.

@article{NouriShirazi2015NicotineEA,
  title={Nicotine exposure alters the mRNA expression of Notch ligands in dendritic cells and their response to Th1-/Th2-promoting stimuli.},
  author={Mahyar Nouri-Shirazi and C Kahlden and P Nishino and Elisabeth Guinet},
  journal={Scandinavian journal of immunology},
  year={2015},
  volume={81 2},
  pages={110-20}
}
Dendritic cells (DCs) utilize polarizing signals to instruct the differentiation of T helper (Th) cells into Th1 and Th2 effector cells: antigen-specific 'signal 1', costimulatory 'signal 2' and polarizing cytokines 'signal 3'. Accumulating evidence suggests the involvement of an additional signal, the Notch signalling pathway. We reported that in response… CONTINUE READING