Nicotine evokes cell death in embryonic rat brain during neurulation.

  title={Nicotine evokes cell death in embryonic rat brain during neurulation.},
  author={Tara Sankar Roy and James E. Andrews and Frederic J. Seidler and Theodore A. Slotkin},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={287 3},
Maternal cigarette smoking during pregnancy represents the most prevalent exposure to a suspected neuroteratogen, nicotine. Although animal models have demonstrated brain cell loss and synaptic abnormalities after prenatal nicotine exposure, the multiple effects of nicotine on the maternal-fetal unit make it difficult to prove that nicotine itself is a neuroteratogen. In the current study, whole rat embryo culture was used to study the effects of nicotine at the neural tube stage of development… CONTINUE READING
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Prenatal exposure to nicotine: What can we learn from animal models? in Maternal Substance Abuse and the Developing Nervous System (Zagon IS and Slotkin TA eds), pp 97–124

  • TA Slotkin
  • 1992
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