Nicotine during pregnancy: changes induced in neurotransmission, which could heighten proclivity to addict and induce maladaptive control of attention

@article{Kohlmeier2014NicotineDP,
  title={Nicotine during pregnancy: changes induced in neurotransmission, which could heighten proclivity to addict and induce maladaptive control of attention},
  author={K. Kohlmeier},
  journal={Journal of Developmental Origins of Health and Disease},
  year={2014},
  volume={6},
  pages={169 - 181}
}
  • K. Kohlmeier
  • Published 2014
  • Medicine
  • Journal of Developmental Origins of Health and Disease
Prenatal exposure to nicotine, occurring either via maternal smoking or via use of transdermal nicotine patches to facilitate cigarette abstinence by pregnant women, is associated with ∼13% of pregnancies worldwide. Nicotine exposure during gestation has been correlated with several negative physiological and psychosocial outcomes, including heightened risk for aberrant behaviors involving alterations in processing of attention as well as an enhanced liability for development of drug dependency… Expand
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Prenatal nicotine exposure alters the subsequent response to nicotine in adolescence, effects that may contribute to the association between maternal smoking during pregnancy and subsequent adolescent smoking in the offspring. Expand
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It is indicated that prenatal nicotine exposure alters parameters of 5HT synaptic communication lasting into adolescence and changes the response to nicotine administration and withdrawal in adolescence, actions which may contribute to a subpopulation especially vulnerable to nicotine dependence. Expand
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Data suggest that PNE induces changes in cholinergic LDT cells that would be expected to alter cellular excitability that may contribute to the particular susceptibility of in utero nicotine exposed individuals to addict to nicotine upon nicotine exposure in the juvenile period. Expand
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The recent development of a model of adolescent nicotine administration in rats that recapitulates the plasma levels of nicotine found in smokers is described, indicating that adolescence represents a unique period of vulnerability for nicotine-induced misprogramming of brain cell development and synaptic function. Expand
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