Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis.

@article{Lee2017NicotineDN,
  title={Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis.},
  author={Jaejoon Lee and Ayala Luria and Christopher N Rhodes and Harini Raghu and Nithya Lingampalli and Orr Sharpe and Bal{\'a}zs Rada and Dong Hyun Sohn and William H Robinson and Jeremy B Sokolove},
  journal={Rheumatology},
  year={2017},
  volume={56 4},
  pages={644-653}
}
Objectives The aim was to investigate the effects of nicotine on neutrophil extracellular traps (NETs) formation in current and non-smokers and on a murine model of RA. Methods We compared spontaneous and phorbol 12-myristate 13-acetate-induced NETosis between current and non-smokers by DNA release binding. Nicotine-induced NETosis from non-smokers was assessed by DNA release binding, NET-specific (myeloperoxidase (MPO)-DNA complex) ELISA and real-time fluorescence microscopy. We also used… CONTINUE READING