Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons.

@article{Biegon2010NicotineBB,
  title={Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons.},
  author={Anat Biegon and Sung-won Kim and Jean Logan and Jacob M. Hooker and Lisa Muench and Joanna S. Fowler},
  journal={Biological psychiatry},
  year={2010},
  volume={67 8},
  pages={774-7}
}
BACKGROUND Cigarette smoking and nicotine have complex effects on human physiology and behavior, including some effects similar to those elicited by inhibition of aromatase, the last enzyme in estrogen biosynthesis. We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase. METHODS Brain aromatase availability was examined with positron emission tomography and the selective aromatase inhibitor [(11)C]vorozole in six… CONTINUE READING
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