Nicotine and nicotinic receptors in the circadian system.

  title={Nicotine and nicotinic receptors in the circadian system.},
  author={Bruce F. O'Hara and Dale M. Edgar and Vinh H. Cao and Steven W. Wiler and H. Craig Heller and Thomas S Kilduff and J. Douglas Miller},
  volume={23 2},
Considerable data support a role for cholinergic influences on the circadian system. The extent to which these influences are mediated by nicotinic acetylcholine receptors (nAChRs) has been controversial, as have the specific actions of nicotine and acetylcholine in the suprachiasmatic nucleus (SCN) of the hypothalamus. In this article we review the existing literature and present new data supporting an important role for nAChRs in both the developing and adult SCN. Specifically, we present… CONTINUE READING