Nicotine and nicotinic receptor antagonists potentiate the antidepressant-like effects of imipramine and citalopram.

@article{Popik2003NicotineAN,
  title={Nicotine and nicotinic receptor antagonists potentiate the antidepressant-like effects of imipramine and citalopram.},
  author={Piotr Popik and Ewa Kozela and Martyna Krawczyk},
  journal={British journal of pharmacology},
  year={2003},
  volume={139 6},
  pages={
          1196-202
        }
}
1. Epidemiological and clinical observations suggest the involvement of nicotinic acetylcholine receptors (nAChRs) in depressive illness. Nonetheless, there is no clearcut evidence that nicotine and/or nAChR antagonists produce an antidepressant effect. 2. In the tail-suspension test (C57/Bl male mice), nicotine (0.8-1.2 mg kg(-1) s.c. or i.p.) given 15-60 min before the measurement exerted no effect on immobility. 3. Given 30 min before the measurement, citalopram (2 mg kg(-1)) produced a… CONTINUE READING
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