Nicotine and endogenous opioids: Neurochemical and pharmacological evidence
@article{Hadjiconstantinou2011NicotineAE, title={Nicotine and endogenous opioids: Neurochemical and pharmacological evidence}, author={Maria Hadjiconstantinou and Norton H. Neff}, journal={Neuropharmacology}, year={2011}, volume={60}, pages={1209-1220} }
73 Citations
Dopaminergic and cholinergic learning mechanisms in nicotine addiction
- Biology, PsychologyAnnals of the New York Academy of Sciences
- 2015
This work focuses on the acquisition phase of smoking addiction and reviews animal model studies on how nicotine modifies dopaminergic and cholinergic signaling in key nodes of the reinforcement circuitry: ventral tegmental area, nucleus accumbens, amygdala, and hippocampus.
Chronic Nicotine Treatment Impacts the Regulation of Opioid and Non-opioid Peptides in the Rat Dorsal Striatum*
- Biology, PsychologyMolecular & Cellular Proteomics
- 2013
Nicotine altered levels of nine non-opioid peptides derived from precursors, including somatostatin and cerebellin, which potentially modulate neurotransmitter release and energy metabolism and suggests that apart from the opioid peptides, several other peptidergic systems are involved in the preoccupation/craving phase of drug dependence.
Repeated nicotine exposure modulates prodynorphin and pronociceptin levels in the reward pathway.
- Biology, MedicineDrug and alcohol dependence
- 2016
On the Role of Cannabinoid CB1- and μ-Opioid Receptors in Motor Impulsivity
- Biology, PsychologyFront. Pharmacol.
- 2012
Investigation of whether cannabinoid CB1 and/or μ-opioid receptors are involved in nicotine-induced impulsivity showed that the cannabinoidCB1 receptor antagonist SR141716A, but not the opioid receptor antagonist naloxone, reduced Nicotine-induced premature responding, indicating that nicotine- induced motor impulsivity is cannabinoid, butNot opioid receptor-dependent.
Involvement of Opioid Receptors in Nicotine-Related Reinforcement and Pleasure
- Biology, PsychologyNeuroscience of Nicotine
- 2019
The modulatory role of nicotine on cognitive and non-cognitive functions
- Biology, PsychologyBrain Research
- 2019
Neurophysiology of Nicotine Addiction.
- Biology, PsychologyJournal of addiction research & therapy
- 2011
Two general neural systems are emerging as critical for the initiation and maintenance of tobacco use and particular nAChR subtypes have roles that contribute to the overall nicotine addiction process.
Nicotinic, glutamatergic and dopaminergic synaptic transmission and plasticity in the mesocorticolimbic system: Focus on nicotine effects
- BiologyProgress in Neurobiology
- 2015
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Neurobiological mechanisms involved in nicotine dependence and reward: Participation of the endogenous opioid system
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It is proposed that nicotine influences Dyn primarily through dopamine release and that glutamate plays a modulatory role and a heightened dynorphinergic tone may contribute to the aversive effects of nicotine in naive animals and first-time tobacco smokers.