Nicotine and endogenous opioids: Neurochemical and pharmacological evidence

@article{Hadjiconstantinou2011NicotineAE,
  title={Nicotine and endogenous opioids: Neurochemical and pharmacological evidence},
  author={Maria Hadjiconstantinou and N. Neff},
  journal={Neuropharmacology},
  year={2011},
  volume={60},
  pages={1209-1220}
}
Although the mesolimbic dopamine hypothesis is the most influential theory of nicotine reward and reinforcement, there has been a consensus that other neurotransmitter systems contribute to the addictive properties of nicotine as well. In this regard, the brain opioidergic system is of interest. Striatum is rich in opioid peptides and opioid receptors, and striatal opioidergic neurons are engaged in a bidirectional communication with midbrain dopaminergic neurons, closely regulating each other… Expand
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  • 16
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  • 49
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  • 15
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  • 45
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  • 290
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References

SHOWING 1-10 OF 234 REFERENCES
Endogenous opioid systems and alcohol addiction
  • A. Herz
  • Chemistry, Medicine
  • Psychopharmacology
  • 1997
  • 687
Nicotine and Endogenous Opioids: Toward Specific Pharmacotherapy
  • Z. Ismail, N. El-guebaly
  • Philosophy, Medicine
  • Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 1998
  • 20
Reward processing by the opioid system in the brain.
  • 641
  • PDF
...
1
2
3
4
5
...