• DOI:10.1016/j.neuropharm.2010.11.010
Corpus ID: 45539554

Nicotine and endogenous opioids: Neurochemical and pharmacological evidence

@article{Hadjiconstantinou2011NicotineAE,
  title={Nicotine and endogenous opioids: Neurochemical and pharmacological evidence},
  author={Maria Hadjiconstantinou and N. Neff},
  journal={Neuropharmacology},
  year={2011},
  volume={60},
  pages={1209-1220}
}

• Maria Hadjiconstantinou, N. Neff
• Published 2011
• Medicine
• Neuropharmacology

Although the mesolimbic dopamine hypothesis is the most influential theory of nicotine reward and reinforcement, there has been a consensus that other neurotransmitter systems contribute to the addictive properties of nicotine as well. In this regard, the brain opioidergic system is of interest. Striatum is rich in opioid peptides and opioid receptors, and striatal opioidergic neurons are engaged in a bidirectional communication with midbrain dopaminergic neurons, closely regulating each other… Expand

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