Nicotine and acetylcholine induce release of calcitonin gene-related peptide from rat trachea.

@article{Jinno1994NicotineAA,
  title={Nicotine and acetylcholine induce release of calcitonin gene-related peptide from rat trachea.},
  author={Shuji Jinno and X Y Hua and Tony L. Yaksh},
  journal={Journal of applied physiology},
  year={1994},
  volume={76 4},
  pages={1651-6}
}
In the present study, we observed that nicotine, the nicotinic analogue cytisine, and acetylcholine (ACh) evoked a concentration-dependent (5 x 10(-6)-5 x 10(-5) M) release of calcitonin gene-related peptide (CGRP) from the rat trachea. After a prolonged exposure to capsaicin, nicotine-induced CGRP release was absent, suggesting that the release of CGRP by nicotine is derived from capsaicin-sensitive afferent terminals. Nicotine- and cytisine-induced release displayed a significant degree of… CONTINUE READING

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