Nicotine activates the chemosensory cation channel TRPA1

@article{Talavera2009NicotineAT,
  title={Nicotine activates the chemosensory cation channel TRPA1},
  author={Karel Talavera and Maarten Gees and Yuji Karashima and V{\'i}ctor M. Meseguer and Jeroen A. J. Vanoirbeek and Nils Damann and Wouter Everaerts and M{\'e}lissa Benoit and Annelies Janssens and Rudi Vennekens and F{\'e}lix Viana and Benoit Nemery and Bernd Nilius and Thomas Voets},
  journal={Nature Neuroscience},
  year={2009},
  volume={12},
  pages={1293-1299}
}
Topical application of nicotine, as used in nicotine replacement therapies, causes irritation of the mucosa and skin. This reaction has been attributed to activation of nicotinic acetylcholine receptors (nAChRs) in chemosensory neurons. In contrast with this view, we found that the chemosensory cation channel transient receptor potential A1 (TRPA1) is crucially involved in nicotine-induced irritation. We found that micromolar concentrations of nicotine activated heterologously expressed mouse… 
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