Nicotine activates the chemosensory cation channel TRPA1

  title={Nicotine activates the chemosensory cation channel TRPA1},
  author={Karel Talavera and Maarten Gees and Yuji Karashima and V{\'i}ctor M. Meseguer and Jeroen A. J. Vanoirbeek and Nils Damann and Wouter Everaerts and M{\'e}lissa Benoit and Annelies Janssens and Rudi Vennekens and F{\'e}lix Viana and Benoit Nemery and Bernd Nilius and Thomas Voets},
  journal={Nature Neuroscience},
Topical application of nicotine, as used in nicotine replacement therapies, causes irritation of the mucosa and skin. This reaction has been attributed to activation of nicotinic acetylcholine receptors (nAChRs) in chemosensory neurons. In contrast with this view, we found that the chemosensory cation channel transient receptor potential A1 (TRPA1) is crucially involved in nicotine-induced irritation. We found that micromolar concentrations of nicotine activated heterologously expressed mouse… 
The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa
All three relevant irritant receptors are functionally expressed in the oral mucosa and play their specific roles in inducing neurogenic inflammation and sensitization to heat and cold.
Four Irritating Odorants Target the Trigeminal Chemoreceptor TRPA1
This study suggests that TRPA1 is required for detection of α-terpineol, benzaldehyde, and toluene as trigeminal irritants in vivo, but is likely only one of multiple trig eminal receptors detecting amyl acetate.
Differential effects of bitter compounds on the taste transduction channels TRPM5 and IP3 receptor type 3.
It is found that nicotine inhibits TRPM5 currents with an effective inhibitory concentration of ~1.3mM at -50 mV, implying the existence of a TR PM5-independent pathway for the detection of nicotine bitterness.
Borneol inhibits TRPA1, a proinflammatory and noxious pain-sensing cation channel.
It was found that borneol inhibits TRPA1 mediated cationic currents in low millimolar range (IC50 0.3mM) in heterologous expression systems like Xenopus oocytes and in neurons cultured from trigeminal ganglia, and could be a safer therapeutic-combination in clinical situations whereTRPA1 channelopathies like neuropathic-pain, trigemINAL neuralgia or nicotine withdrawal treatments are involved.
Cigarette smoke has sensory effects through nicotinic and TRPA1 but not TRPV1 receptors on the isolated mouse trachea and larynx
Nicotinic receptors contribute to the sensory effects of cigarette smoke on the trachea, which are dominated by TRPA1, as well as of typical constituents, such as nicotine and reactive carbonyls.
Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine
It is concluded that nAChRs expressed in a subset of taste cells serve as common receptors for the detection of the TRPM5-independent bitter taste of nicotine, acetylcholine and ethanol.
Agonist-induced sensitisation of the irritant receptor ion channel TRPA 1 Running title : Agonist-induced sensitisation of TRPA 1
It is shown that in the absence of extracellular calcium the current passing through TRPA1 gradually increases (sensitises) during prolonged application of agonists, and is therefore intrinsic to the channel.
Role of Chemosensory TRP Channels in Lung Cancer
A synopsis of data on the expression of chemosensory TRP channels in lung cancer cells is presented and TRP agonists andTRP-dependent signaling pathways with potential relevance to tumor biology are described.


Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.
Several new effects of nicotine on channels involved in nociception are document and indicate how they may impact physiological processes involving pain and gustation.
Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1
The data indicate that TRPA1 is a highly sensitive menthol receptor that very likely contributes to the diverse psychophysical sensations after topical application of menthol to the skin or mucous membranes of the oral and nasal cavities.
Cough sensors. IV. Nicotinic membrane receptors on cough sensors.
Findings suggest that the tussive effect of nicotine is probably mediated through an activation of nicotinic acetylcholine receptors (nAChRs) expressed on the sensory terminals of cough receptors located in the airway mucosa.
Transient Receptor Potential Channels in Sensory Neurons Are Targets of the Antimycotic Agent Clotrimazole
The results identify TRP channels in sensory neurons as molecular targets of CLT, and offer means to develop novel CLT preparations with fewer unwanted sensory side effects.
TRPA1 channels: Novel targets of 1,4-dihydropyridines
Nifedipine is identified as a new molecular target for the 1,4-dihydropyridine class of calcium channel modulators and nicardipine and nitrendipine are identified as structurally related L-type calcium channel agonists.
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and is
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.
Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel,
Potentiation of evoked calcitonin gene‐related peptide release from oral mucosa: a potential basis for the pro‐inflammatory effects of nicotine
The hypothesis that nicotinic agents, acting at nAChRs contained on primary sensory neurons, are capable of directly modulating the stimulated release of iCGRP is supported.