Nicotine absorption and the subjective and physiologic effects of nicotine toothpicks

  title={Nicotine absorption and the subjective and physiologic effects of nicotine toothpicks},
  author={Markus Hasenfratz and Karl B{\"a}ttig},
  journal={Clinical Pharmacology \& Therapeutics},
This study investigated a new tobacco‐free smoking substitute intended to provide not only the nicotine but also, to some extent, the manipulative component of the smoking act. Nicotine uptake and cardiovascular and subjective effects of nicotine‐containing toothpicks (4 mg) were compared with those of nicotine chewing gum (4 mg). After the two products were chewed for 5 minutes, the nicotine uptake from the toothpick was twofold that of the gum. However, comparing the total nicotine deliveries… 

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