Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway

@article{Ye2004NicotinePC,
  title={Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway},
  author={Yi Ni Ye and Edgar S. L. Liu and Vivian Yvonne Shin and William Ka Kei Wu and Jiing‐Chyuan Luo and Chi Hin Cho},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={308},
  pages={66 - 72}
}
  • Y. Ye, E. S. Liu, C. Cho
  • Published 1 January 2004
  • Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco, has been implicated as playing a role in carcinogenesis. Our previous study showed that passive cigarette smoking promoted inflammation-associated colonic adenoma formation in mice, and 5-lipoxygenase (5-LOX) plays an important role in this process. In the present study, we aimed to investigate whether nicotine could stimulate colon cancer cell proliferation and tumor growth in nude mice xenograft model and the… 

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