Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway

  title={Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway},
  author={Y. Ye and E. S. Liu and V. Shin and W. Wu and J. C. Luo and C. Cho},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={66 - 72}
  • Y. Ye, E. S. Liu, +3 authors C. Cho
  • Published 2004
  • Medicine
  • Journal of Pharmacology and Experimental Therapeutics
Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco, has been implicated as playing a role in carcinogenesis. Our previous study showed that passive cigarette smoking promoted inflammation-associated colonic adenoma formation in mice, and 5-lipoxygenase (5-LOX) plays an important role in this process. In the present study, we aimed to investigate whether nicotine could stimulate colon cancer cell proliferation and tumor growth in nude mice xenograft model and the… Expand
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