Nicotine Induces Sensitization of Turning Behavior in 6-Hydroxydopamine Lesioned Rats

@article{Gregrio2009NicotineIS,
  title={Nicotine Induces Sensitization of Turning Behavior in 6-Hydroxydopamine Lesioned Rats},
  author={Michele Lima Greg{\'o}rio and Evellyn Claudia Wietzikoski and Marcelo Machado Ferro and Jo{\~a}o Miguel Lourenço Silveira and Maria Aparecida Barbato Fraz{\~a}o Vital and Claudio Ribeiro da Cunha},
  journal={Neurotoxicity Research},
  year={2009},
  volume={15},
  pages={359-366}
}
Nicotinic drugs have been proposed as putative drugs to treat Parkinson’s disease (PD). In this study, we investigated whether nicotine can sensitize parkinsonian animals to the effect of dopaminergic drugs. Testing this hypothesis is important because nicotine has been shown to present neuroprotective and acute symptomatic effects on PD, but few studies have addressed the question of whether it may induce long-lasting effects on dopamine neurotransmission. We tested this hypothesis in the 6… CONTINUE READING

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