Nicotine: specific role in angiogenesis, proliferation and apoptosis

@article{Cardinale2012NicotineSR,
  title={Nicotine: specific role in angiogenesis, proliferation and apoptosis},
  author={Alessio Cardinale and Candida Nastrucci and Alfredo Cesario and Patrizia Russo},
  journal={Critical Reviews in Toxicology},
  year={2012},
  volume={42},
  pages={68 - 89}
}
Nowadays, tobacco smoking is the cause of ~5–6 million deaths per year, counting 31% and 6% of all cancer deaths (affecting 18 different organs) in middle-aged men and women, respectively. Nicotine is the addictive component of tobacco acting on neuronal nicotinic receptors (nAChR). Functional nAChR, are also present on endothelial, haematological and epithelial cells. Although nicotine itself is regularly not referred to as a carcinogen, there is an ongoing debate whether nicotine functions as… 
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