Nicotinamide reduces hypoxic ischemic brain injury in the newborn rat.

@article{Feng2006NicotinamideRH,
  title={Nicotinamide reduces hypoxic ischemic brain injury in the newborn rat.},
  author={Yangzheng Feng and Ian A. Paul and Michael H Leblanc},
  journal={Brain research bulletin},
  year={2006},
  volume={69 2},
  pages={117-22}
}
Nicotinamide reduces ischemic brain injury in adult rats. Can similar brain protection be seen in newborn animals? Seven-day-old rat pups had the right carotid artery permanently ligated followed by 2.5 h of 8% oxygen. Nicotinamide 250 or 500 mg/kg was administered i.p. 5 min after reoxygenation, with a second dose given at 6 h after the first. Brain damage… CONTINUE READING