Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.

@article{Zhang2013NicotinamidePP,
  title={Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.},
  author={Jun-gang Zhang and Gang Zhao and Qi Qin and Bo Wang and Lin Wei Liu and Yang Liu and Shi-chang Deng and Kui Tian and Chun-you Wang},
  journal={Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]},
  year={2013},
  volume={13 2},
  pages={140-6}
}
BACKGROUND Nicotinamide (NAM), the precursor for the synthesis of NAD(+) and also an inhibitor of SIRT1, has been discovered to inhibit some types of cancer. However, little is known about the effects of NAM on pancreatic cancer cells. Since previous research showed that SIRT1 and K-Ras/Akt signaling acted as a promoter in tumorigenesis of pancreatic cancer, our present research set out to explore whether NAM inhibits proliferation and facilitates chemosensitivity in pancreatic cancer cells as… CONTINUE READING
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